Amalie,
Please post the name of your country and the world on which it is based, so that people can look at your country to be able to see what is going wrong.
Without being able to see your country, I can only provide general advice...
I am not aware of any bugs that cause supply quality to be changed automatically.
When setting supply quality, make sure you press the "Save Order Quantities and Quality" button, at the bottom of the page, or the game won't save your changes.
Even so, 180 Quality is a reasonable quality for Corporation supplies, and won't cause you to be losing money, something else is causing your loses.
Also, I'm not aware of any setting called "Skip All" what are you referring to?
Signed President of DanNation on LU