Well... the help automation isn't really very helpful, BUT, if you are brand new and haven't even started to figure things out you might do well to leave them all on. When you feel you know a bit of how it works, turn all the help automation off.
If we are talking about just settings for corporations on that page... turn hiring/production to manual 100%, upgrades is down to you depending on how you manage your economy (I recommend auto upgrade if you're selling on world market), same for salaries (200 - 300) and sell/buy strategy is another issue altogether, I think you can only buy at best price as a new/free player, be sure to sell at a higher value than what you make, eg, make Q200, sell at 230), dropping by 10% monthly if not sold, follow quality. These are only rough guide lines, dont swear by them, try other strategies as you grow.