An empire offers more population with which to build up a profitable economic base. The start up costs are a little imposing if you're not too wealthy, but manageable. I would work to build your main to 30M population, then take a slave build it to at least 30M, and repeat. At maximum, once all the countries you currently own have reached 50M+ you should take a new country so you don't need to deal with population losses which can add up.
If you remain at War Level 2 or below, you don't need to worry about anyone attacking you.
In essence: more people = more profit.
Strategically, it's pretty much the same thing: more people = more military.